Viral Vector Core

Andelyn Biosciences’ Viral Vector Core comprises of laboratory space reserved to manufacture research grade AAV vectors that support preclinical studies such as pilot, proof-of-concept, dose confirmation and IND-enabling toxicology studies.

The Viral Vector Core manufactures research grade AAV vectors for both academic institutes and biopharmaceutical clients. These viral vectors are used for preclinical research studies which support the development of future clinical AAV gene therapy products.

At our Viral Vector Core, we use state-of-the-art equipment, time-tested techniques, and advanced design concepts to provide our viral vector development and manufacturing services. Andelyn Biosciences is dedicated to using the latest techniques and tools for both process and analytical development.

Andelyn Biosciences Viral Vector Core
Using the Akta Pure 150L to perform chromatographical purification of AAV vectors.

Viral Vector Services

At Andelyn Biosciences, we’re an ideal viral vector CDMO partner. We will work closely with you throughout the entire process of developing your gene therapy or vaccine – from the initial process of development and research to creating a reliable and consistent clinical and commercial supply. Andelyn Biosciences is with you every step of the way.

We bring years of experience to the table, with unique manufacturing processes and the ability to produce a wide variety of cGMP viral vectors – including AAV.

Our current lineup of vector services includes:

  • Standard Research Grade Productions (Adherent) 
    • Small Scale: approximately 1E+12 total vg
    • Medium Scale: approximately 5E+12 total vg
    • Large Scale: approximately 1E+13 total vg
  • Custom Scale CellSTACK and HYPERStack® productions
  • Standard Research Grade Productions (Suspension) 
    • Small, Medium & Large scale
  • Toxicology Grade Productions 
    • 5, 10, 20 or 30 HYPERStacks® (adherent)
    • 50L Bioreactor (suspension)
    • Manufactured using single-use materials
    • All USP/NF grade reagents
    • All information recorded in solution prep forms and research batch records
    • Research Grade and Toxicology Grade Diluent
    • Yield Assessment and/or Engineering Assessment

That’s not all. If you don’t see the viral vector services you need on this list, contact Andelyn Biosciences right away to discuss your project in further detail, and to learn more about our capabilities and services.

Viral Vector Technologies

Andelyn Biosciences Viral Vector Core
As a high-throughput laboratory, AAV vectors are manufactured to support pilot studies up through IND-enabling toxicology studies.

We specialize in both AAV (Adeno-associated virus) manufacturing for gene therapy applications, as well as lentivirus manufacturing for gene therapy.

That’s not all, though. Using our advanced technology and expertise, Andelyn Biosciences can also help in the creation of many other viral vectors. Our teams have years of experience in providing both lenti process development and GMP production services. We can use stable packaging cell-line based processes, as well as transient transfection processes to develop viral vectors.

We are fully capable of producing vectors with either suspension-based platforms or adherent platforms – and our facility is flexible and versatile enough to address your specific needs, no matter what they may be.

Why Andelyn Biosciences? Your Ideal Partner For Viral Vector Services

Andelyn Biosciences has a stellar track record and pedigree. We have more than 20 years of combined experience manufacturing vectors, and have supplied major pharmaceutical companies and biopharma companies with a wide variety of vectors.

Our Viral Vector Core is capable of creating a diversity of products with multiple serotypes and distinct purification processes, ensuring we’re a “one-stop-shop” for vector manufacturing. And by working closely with our partners and their R&D teams as we develop your product, we ensure that you get the best possible results.

For more information or to discuss your need for viral vector services in more detail, contact Andelyn Biosciences today. Our team is always prepared to discuss your project, its viability, and how we can help with our viral vector manufacturing services.